TRIM36 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA868285LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TRIM36 Polyclonal antibody

Uniprot No.

Q9NQ86

Target Names

TRIM36

Alternative Names

Acrosome RBCC protein antibody; E3 ubiquitin protein ligase TRIM36 antibody; E3 ubiquitin-protein ligase Trim36 antibody; Haprin antibody; RBCC728 antibody; RING finger protein 98 antibody; RNF98 antibody; TRI36_HUMAN antibody; TRIM 36 antibody; Trim36 antibody; Tripartite motif containing 36 antibody; Tripartite motif containing protein 36 antibody; Tripartite motif protein 36 antibody; Tripartite motif-containing protein 36 antibody; Zinc binding protein Rbcc728 antibody; Zinc-binding protein Rbcc728 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human E3 ubiquitin-protein ligase TRIM36 protein (70-280AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.

Gene References into Functions

aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure PMID: 28359976
The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly . PMID: 28087737
TRIM36 is the causative gene for autosomal recessive anencephaly PMID: 28087737
The overexpression of the TRIM36 in the vast majority of prostate cancer suggest that this gene might be involved in the prostate tumorigenesis. PMID: 15145053
molecular cloning and characterization of a human haprin ortholog. PMID: 15955891
TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H, potentially associated with chromosome segregation and its excess may cause chromosomal instability. PMID: 19232519

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Involvement in disease

Anencephaly (ANPH)

Subcellular Location

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton.

Protein Families

TRIM/RBCC family

Tissue Specificity

Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. Expressed in fetal tissues.

Database Links

HGNC: 16280

OMIM: 206500

KEGG: hsa:55521

STRING: 9606.ENSP00000282369

UniGene: Hs.519514

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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